The Multi-sensor dataset of environmental conditions in smart home consists of time series data acquired from sensors deployed in indoor of a smart domestic room located in Montalto Uffugo (CS) Italy, for environmental monitoring. Various sensors were used for recording data including temperature, humidity, CO2, noise and pressure. Raw sensor data samples were collected continuously at regular time intervals of about 5 minutes over a period from 5 of March 2023 to 4 of September 2023. The dataset can be useful in the analysis of different tasks, including data-driven algorithms for analyzing the comfort of people. In particular, the research community might be interested in investigating information extraction and decision making applied to smart homes. Furthermore, by applying artificial intelligence (AI) algorithms on such data collected over long periods, it is possible to extract, e.g., patterns that reveal environmental changes in the domestic living conditions.